{
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  "Type": "Package",
  "Title": "Retrieve and Analyze Clinical Trials Data from Public Registers",
  "Version": "1.26.1.9000",
  "Date": "2026-03-08",
  "URL": "https://cran.r-project.org/package=ctrdata,\nhttps://rfhb.github.io/ctrdata/",
  "BugReports": "https://github.com/rfhb/ctrdata/issues",
  "Description": "A system for querying, retrieving and analyzing protocol-\nand results-related information on clinical trials from four\npublic registers, the 'European Union Clinical Trials Register'\n('EUCTR', <https://www.clinicaltrialsregister.eu/>),\n'ClinicalTrials.gov' (<https://clinicaltrials.gov/> and also\ntranslating queries the retired classic interface), the\n'ISRCTN' (<http://www.isrctn.com/>) and the 'European Union\nClinical Trials Information System' ('CTIS',\n<https://euclinicaltrials.eu/>). Trial information is\ndownloaded, converted and stored in a database ('PostgreSQL',\n'SQLite', 'DuckDB' or 'MongoDB'; via package 'nodbi').\nProtocols, statistical analysis plans, informed consent sheets\nand other documents in registers associated with trials can\nalso be downloaded. Other functions implement trial concepts\ncanonically across registers, identify deduplicated records,\neasily find and extract variables (fields) of interest even\nfrom complex nested data as used by the registers, merge\nvariables and update queries. The package can be used for\nmonitoring, meta- and trend-analysis of the design and conduct\nas well as of the results of clinical trials across registers.\nSee overview in Herold, R. (2025) <doi:10.1017/rsm.2025.10061>.",
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  "Repository": "https://rfhb.r-universe.dev",
  "Date/Publication": "2026-05-02 15:30:11 UTC",
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  "_exports": [
    "ctrFindActiveSubstanceSynonyms",
    "ctrGenerateQueries",
    "ctrGetQueryUrl",
    "ctrLoadQueryIntoDb",
    "ctrOpenSearchPagesInBrowser",
    "ctrShowOneTrial",
    "dbFindFields",
    "dbFindIdsUniqueTrials",
    "dbGetFieldsIntoDf",
    "dbQueryHistory",
    "dfMergeVariablesRelevel",
    "dfName2Value",
    "dfTrials2Long",
    "f.assignmentType",
    "f.controlType",
    "f.externalLinks",
    "f.hasResults",
    "f.isMedIntervTrial",
    "f.isUniqueTrial",
    "f.likelyPlatformTrial",
    "f.numSites",
    "f.numTestArmsSubstances",
    "f.primaryEndpointDescription",
    "f.primaryEndpointResults",
    "f.resultsDate",
    "f.sampleSize",
    "f.sponsorType",
    "f.startDate",
    "f.statusRecruitment",
    "f.trialObjectives",
    "f.trialPhase",
    "f.trialPopulation",
    "f.trialTitle"
  ],
  "_help": [
    {
      "page": "ctrdata",
      "title": "Getting started, database connection, function overview",
      "topics": [
        "ctrdata"
      ]
    },
    {
      "page": "ctrdata-registers",
      "title": "Information on clinical trial registers",
      "topics": [
        "ctrdata-registers"
      ]
    },
    {
      "page": "ctrdata-trial-concepts",
      "title": "Trial concepts implemented across registers",
      "topics": [
        "ctrdata-trial-concepts"
      ]
    },
    {
      "page": "ctrFindActiveSubstanceSynonyms",
      "title": "Find synonyms of an active substance",
      "topics": [
        "ctrFindActiveSubstanceSynonyms"
      ]
    },
    {
      "page": "ctrGenerateQueries",
      "title": "Generates queries that work across registers",
      "topics": [
        "ctrGenerateQueries"
      ]
    },
    {
      "page": "ctrGetQueryUrl",
      "title": "Get register name and query parameters from search URL",
      "topics": [
        "ctrGetQueryUrl"
      ]
    },
    {
      "page": "ctrLoadQueryIntoDb",
      "title": "Load and store register trial information",
      "topics": [
        "ctrLoadQueryIntoDb"
      ]
    },
    {
      "page": "ctrOpenSearchPagesInBrowser",
      "title": "Open register to show query results or search page",
      "topics": [
        "ctrOpenSearchPagesInBrowser"
      ]
    },
    {
      "page": "ctrShowOneTrial",
      "title": "Show full structure and all data of a trial",
      "topics": [
        "ctrShowOneTrial"
      ]
    },
    {
      "page": "dbFindFields",
      "title": "Find names of fields in the database collection",
      "topics": [
        "dbFindFields"
      ]
    },
    {
      "page": "dbFindIdsUniqueTrials",
      "title": "Get identifiers of deduplicated trial records",
      "topics": [
        "dbFindIdsUniqueTrials"
      ]
    },
    {
      "page": "dbGetFieldsIntoDf",
      "title": "Create data frame of specified fields or trial concepts from database collection",
      "topics": [
        "dbGetFieldsIntoDf"
      ]
    },
    {
      "page": "dbQueryHistory",
      "title": "Show history of queries loaded into collection",
      "topics": [
        "dbQueryHistory"
      ]
    },
    {
      "page": "dfMergeVariablesRelevel",
      "title": "Merge variables, keeping type where possible, optionally relevel factors",
      "topics": [
        "dfMergeVariablesRelevel"
      ]
    },
    {
      "page": "dfName2Value",
      "title": "Get value for variable of interest",
      "topics": [
        "dfName2Value"
      ]
    },
    {
      "page": "dfTrials2Long",
      "title": "Convert data frame with trial records into long format",
      "topics": [
        "dfTrials2Long"
      ]
    },
    {
      "page": "f.assignmentType",
      "title": "Calculate type of assignment to intervention in a study",
      "topics": [
        "f.assignmentType"
      ]
    },
    {
      "page": "f.controlType",
      "title": "Calculate type of control data collected in a study",
      "topics": [
        "f.controlType"
      ]
    },
    {
      "page": "f.externalLinks",
      "title": "Calculate the external references from a study's register record",
      "topics": [
        "f.externalLinks"
      ]
    },
    {
      "page": "f.hasResults",
      "title": "Calculate if a study's results are available",
      "topics": [
        "f.hasResults"
      ]
    },
    {
      "page": "f.isMedIntervTrial",
      "title": "Calculate if study is a medicine-interventional study",
      "topics": [
        "f.isMedIntervTrial"
      ]
    },
    {
      "page": "f.isUniqueTrial",
      "title": "Calculate if record is unique for a study",
      "topics": [
        "f.isUniqueTrial"
      ]
    },
    {
      "page": "f.likelyPlatformTrial",
      "title": "Calculate if study is likely a platform trial or not",
      "topics": [
        "f.likelyPlatformTrial"
      ]
    },
    {
      "page": "f.numSites",
      "title": "Calculate number of sites of a study",
      "topics": [
        "f.numSites"
      ]
    },
    {
      "page": "f.numTestArmsSubstances",
      "title": "Calculate number of arms or groups with investigational medicines in a study",
      "topics": [
        "f.numTestArmsSubstances"
      ]
    },
    {
      "page": "f.primaryEndpointDescription",
      "title": "Calculate details of a primary endpoint of a study",
      "topics": [
        "f.primaryEndpointDescription"
      ]
    },
    {
      "page": "f.primaryEndpointResults",
      "title": "Calculate details of a study's primary endpoint statistical testing",
      "topics": [
        "f.primaryEndpointResults"
      ]
    },
    {
      "page": "f.resultsDate",
      "title": "Calculate date of results of a study",
      "topics": [
        "f.resultsDate"
      ]
    },
    {
      "page": "f.sampleSize",
      "title": "Calculate sample size of a study",
      "topics": [
        "f.sampleSize"
      ]
    },
    {
      "page": "f.sponsorType",
      "title": "Calculate type of sponsor of a study",
      "topics": [
        "f.sponsorType"
      ]
    },
    {
      "page": "f.startDate",
      "title": "Calculate start date of a study",
      "topics": [
        "f.startDate"
      ]
    },
    {
      "page": "f.statusRecruitment",
      "title": "Calculate status of recruitment of a study",
      "topics": [
        "f.statusRecruitment"
      ]
    },
    {
      "page": "f.trialObjectives",
      "title": "Calculate objectives of a study",
      "topics": [
        "f.trialObjectives"
      ]
    },
    {
      "page": "f.trialPhase",
      "title": "Calculate phase of a clinical trial",
      "topics": [
        "f.trialPhase"
      ]
    },
    {
      "page": "f.trialPopulation",
      "title": "Calculate in- and exclusion criteria and age groups",
      "topics": [
        "f.trialPopulation"
      ]
    },
    {
      "page": "f.trialTitle",
      "title": "Calculate the title of a study",
      "topics": [
        "f.trialTitle"
      ]
    }
  ],
  "_readme": "https://github.com/rfhb/ctrdata/raw/HEAD/README.md",
  "_rundeps": [
    "askpass",
    "base64enc",
    "bit",
    "bit64",
    "bslib",
    "cachem",
    "cli",
    "clipr",
    "cpp11",
    "crayon",
    "curl",
    "DBI",
    "digest",
    "dplyr",
    "evaluate",
    "fastmap",
    "fontawesome",
    "fs",
    "generics",
    "glue",
    "highr",
    "hms",
    "htmltools",
    "htmlwidgets",
    "httr",
    "httr2",
    "jqr",
    "jquerylib",
    "jsonlite",
    "knitr",
    "lazyeval",
    "lifecycle",
    "lubridate",
    "magrittr",
    "memoise",
    "mime",
    "nodbi",
    "openssl",
    "pillar",
    "pkgconfig",
    "prettyunits",
    "progress",
    "purrr",
    "R.methodsS3",
    "R.oo",
    "R.utils",
    "R6",
    "rappdirs",
    "Rcpp",
    "readr",
    "rlang",
    "rmarkdown",
    "rvest",
    "sass",
    "selectr",
    "stringdist",
    "stringi",
    "stringr",
    "sys",
    "tibble",
    "tidyr",
    "tidyselect",
    "timechange",
    "tinytex",
    "tzdb",
    "utf8",
    "uuid",
    "V8",
    "vctrs",
    "vroom",
    "withr",
    "xfun",
    "xml2",
    "yaml",
    "zip"
  ],
  "_vignettes": [
    {
      "source": "ctrdata_install.Rmd",
      "filename": "ctrdata_install.html",
      "title": "Install R package ctrdata",
      "author": "Ralf Herold",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Install package ctrdata on an R system",
        "Databases to use",
        "Attach package ctrdata",
        "Credit to clinical trial registers",
        "Quote or reference ctrdata"
      ],
      "created": "2020-10-16 18:34:52",
      "modified": "2026-03-07 18:20:38",
      "commits": 30
    },
    {
      "source": "ctrdata_retrieve.Rmd",
      "filename": "ctrdata_retrieve.html",
      "title": "Retrieve clinical trial information",
      "author": "Ralf Herold",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Get started",
        "Attach package ctrdata",
        "Open register's advanced search page in browser",
        "Adjust search parameters and execute search in browser",
        "Copy address from browser address bar to clipboard",
        "Get address from clipboard",
        "Connect database, retrieve, transform, save and check",
        "Loading only a single version of EUCTR protocol-related data",
        "Repeat and update a previous query",
        "Results-related trial information",
        "Add trial information from several registers",
        "Add personal annotations",
        "Find synonyms of active substance names",
        "Find platform trials",
        "Load information using trial identifiers"
      ],
      "created": "2020-10-16 18:34:52",
      "modified": "2026-03-07 18:20:38",
      "commits": 47
    },
    {
      "source": "ctrdata_summarise.Rmd",
      "filename": "ctrdata_summarise.html",
      "title": "Summarise and analyse clinical trial information",
      "author": "Ralf Herold",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Preparations",
        "Find fields / variables of interest",
        "Data frame from database",
        "Metadata from data frame",
        "De-duplicate records",
        "Use trial concepts to simplify analyses",
        "Reviewing a specific trial",
        "Simple analysis of dates",
        "Cross-register clinical trial concepts",
        "Merging fields for analysis",
        "Historic versions of trial records and changes in sample sizes",
        "Analysing nested fields such as trial results",
        "Analysing primary endpoints",
        "Analysis methods and p values",
        "Investigational or authorised medicinal product?",
        "Analyses using MongoDB pipeline",
        "Aggregation",
        "Mapreduce"
      ],
      "created": "2021-12-04 20:31:24",
      "modified": "2026-03-07 18:20:38",
      "commits": 38
    }
  ],
  "_score": 8.032336659845736,
  "_indexed": true,
  "_nocasepkg": "ctrdata",
  "_universes": [
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  ],
  "_binaries": [
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      "status": "success",
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    {
      "r": "4.5.3",
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      "buildurl": "https://github.com/r-universe/rfhb/actions/runs/26739821955"
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  ]
}